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Figure 9
A schematic summary of the main findings. Prpf31 is required for the maintenance of RPCs and retinal neurogenesis in zebrafish. In the absence of Prpf31, the splicing of genes related to mitosis and DNA repair is compromised, resulting in decreased expression and abnormal functions of these genes. RPCs could not complete the mitotic progression and deal with DNA damages, and finally undergo apoptosis.
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Full text @ Nucleic Acids Res.