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Fig. 7 Proposed model of regulation of the activity of cardiac TREEs in uninjured and regenerating hearts. In uninjured embryonic hearts, cardiac TREEs are inactive; they are activated upon injury. Repression of cardiac TREEs is not functional in the heart in early development. During maturation, cardiac TREEs are actively repressed to prevent aberrant activation in uninjured tissues. Upon injury, the dual function of distinct cis-regulatory elements restricts cardiac TREE activation to the wounded area.
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