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Fig. S3
SU5402 and AG1478 effectively blocks FGFR and EGFR signaling in zebrafish. (a) 24 hpf embryos were treated with water containing DMSO, 0.3 μM BMS-754807 (BMS), or 15 μM SU5402 (SU). After 8 h, the levels of dusp6 mRNA were measured by qRT-PCR and normalized using β-actin mRNA levels. Values shown are mean ± SD, n=3. * P < 0.001 compared to the DMSO group. (b) Embryos were treated with water containing DMSO or 4 μM AG1478 (AG) from 13 to 30 hpf, and subjected to in situ hybridization for crestin. The frequency of embryos with the indicated expression patterns is shown in the bottom right of each panel.
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