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Fig. 7 Embryonic RPCs and postembryonic RSCs share similar expression dynamics of hes family genes. (A) Gene-to-gene correlation of different hes/her genes in 48-hpf RPCs. Yellow squares depict different hes clusters. (B) Heat-map showing the distribution of hes/her genes across different distinct clusters of 48-hpf RPCs. (C) In situ hybridization images of her9 (hes1), her4.2 (hes5) and hes6 in the coronal view of the 48-hpf retinas. The retina boundaries are indicated by the white dashed lines. The areas showing in situ signals (green) are indicated by the region between yellow dashed lines. The nuclei are labeled by DAPI (magenta). Scale bar: 30 μm. (D) Schematic showing the evolution of her9 (hes1), her4.2 (hes5) and hes6 across distinct clusters at a coronal view of the embryonic retina. The emergence order of hes/her family genes is her9 (hes1), her4.2 (hes5) and hes6. (E) Gene-to-gene correlation of different hes/her genes in 14-dpf CMZ progenitor cells. Yellow squares depict different hes clusters. (F) Heat-map showing the distribution of hes/her genes across different distinct clusters of 14-dpf CMZ progenitor cells. (G) In situ hybridization images of her6 (hes1), her4.2 (hes5) and hes6 in the coronal view of the 14-dpf CMZ. The retina boundaries are indicated by the white dashed lines. The areas showing in situ signals (green) are indicated by the region between yellow dashed lines. The nuclei are labeled by DAPI (magenta). Scale bar: 30 μm. (H) Schematic showing the evolution of her6 (hes1), her4.2 (hes5) and hes6 across distinct clusters at a coronal view of the CMZ. The emergence order of hes/her family genes is her6 (hes1), her4.2 (hes5) and hes6.