ZFIN Image: Westphal et al., 2020, Figure 2

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Figure Caption

Figure 2

Dose response curves for selected small molecule inhibitors. (A–J) Dose response curves for HDAC inhibitors (A) Entinostat, (B) Mocetinostat, (C) Vorinostat, for Bromodomain inhibitors (D) Bromosporine, (E) JQ1, (F) I Bet151, for HAT inhibitors (G) PU139, (H) PU141, and for MLL1-WDR5 interaction inhibitors (I) MM102 and (J) OICR9429. Each line represents a specific DA or NA neuron cluster for which a change in th expression was observed. The black dashed line (“lethal”) indicates the percentage of embryos that died at a given compound concentration. Each data point represents the percentage of embryos showing an effect on the specific neuron cluster at the depicted concentration. Abbreviations for dopaminergic clusters: Tc, telencephalon; PrT, pretectum; DC, diencephalic clusters 1–6; noradrenergic clusters; MO, medulla oblongata.

Acknowledgments

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