ZFIN Image: Toms et al., 2019, Fig. 4

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Fig. 4

Retinal vasculature in obe^td15 zebrafish.

OCT en face images of the dorsal retina show inner retinal vessels emerging from the optic nerve region in the wild-type (a) and obe^td15 (b) fish at 12 months post-fertilization, displaying abnormal blood vessel appearance in the mutant retina. Cross-sectional B-scans from wild-type (c) and obe^td15 (d) fish also demonstrate notable differences in vessel size (vessels indicated with *). Numbered brackets (1–4) on the cross-sections represent areas analyzed in the corresponding en face images. Fibrous material was apparent at each depth examined in the vitreous of the obe^td15 retina (3, 4) but was not seen on the wild-type images (1, 2). Hyper-reflective deposits were also noted in the vitreous of the obe^td15 retina on both B-scan (e) and en face (f) images, indicated with arrows. Graph (g) shows retinal vessel thickness plotted against distance from the optic nerve in wild-type and obe^td15 zebrafish. Scale bars = 50 μm.

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Acknowledgments

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Reprinted from Experimental Eye Research, 189, Toms, M., Dubis, A.M., Lim, W.S., Webster, A.R., Gorin, M.B., Moosajee, M., Missense variants in the conserved transmembrane M2 protein domain of KCNJ13 associated with retinovascular changes in humans and zebrafish, 107852, Copyright (2019) with permission from Elsevier. Full text @ Exp. Eye. Res.