ZFIN Image: O'Brown et al., 2019, Figure 5-figure supplement 1.

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Figure Caption

Figure 5-figure supplement 1. <italic>Mfsd2ab</italic> mutants do not have altered BBB permeability.

(A) Representative maximum intensity projection images of the brain of wild-type and mfsd2ab mutants expressing the fluorescently labeled 80 kDa transgenic serum protein DBP-EGFP (green) at 5 dpf. Mfsd2ab mutants have a similarly low level of DBP-EGFP in the midbrain and hindbrain parenchyma compared to wild-type siblings. The scale bar represents 50 µm. (B) Quantification of normalized parenchymal tracer intensity (NHS and DBP-EGFP) in the midbrain and hindbrain of wild-type (black) and mfsd2ab mutants (green). Mfsd2ab mutants display no significant barrier permeability defects, both for the injected NHS and the endogenous transgene DBP-EGFP (A). Each individual fish measured is displayed as a single point. The mean and the standard error are drawn in black.

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Phenotype details

Acknowledgments

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