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Fig. 4
Early signs of functional as well as cellular compensation begin in AL-LC transgenic fish embryos. Increased proliferation as indicated by increased EdU-labeled nuclei (green) were detectable in the 48 hpf transgenic zebrafish hearts compared with control hearts (*P = 0.04) (A). Dimensional analysis to measure cardiac function was performed at 48 hpf as previously described in (23) revealing an increase in stroke volume (*P = 0.03, left) while maintaining a comparable heart rate (B). bpm, beats/min; Con, control; EdU, 5-ethynyl-2′-deoxyuridine; hpf, hours postfertilization; TG, transgenic.
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Full text @ Am. J. Physiol. Heart Circ. Physiol.