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Fig. 3
Excessive PKC signaling promotes the degradation of β-catenin.
a Western blot analysis of β-catenin. b Quantification of the protein level of β-catenin relative to wild-type (WT) group (n = 3 per group, ***p < 0.001, t-test). c The nuclear accumulation of β-catenin is reduced by PMA treatment, d indicated by the quantification of β-catenin+/DAPI+ dots in brain region (n = 6 per group, ***p < 0.001, t-test). e RT-qPCR analysis of the transcriptional target of β-catenin, mycb, axin2 and jun (n = 6 per group, *p < 0.05, t-test)
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