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Fig. 4
Dibenzofuran compounds inhibit melanogenesis in a dose dependent manner. Synchronized embryos were treated with test compounds at the indicated concentrations from 24 hpf for 24 h. The effects on the pigmentation of zebrafish were observed at 48 hpf under the stereomicroscope. Treatment with 0.002 mg/mL had no effect on pigmentation for any of the tested compounds (A,D,G,J). Mild effect on melanogenesis was observed at 0.005 mg/mL (B,E,K). At 0.01 mg/mL there was a strong inhibition of melanogenesis (C,F,L). Compound 3 had no effect at any of the tested concentrations (G–I). Scale bar: 100 μM.
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