ZFIN Image: Gestri et al., 2018, Fig. S2

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Figure Caption

Fig. S2

Figure S2. Failure of choroid fissure fusion in eyes derived from optic vesicles with reduced POM. (A–F) Methylene blue stained sagittal sections through ectopic eyes at 5 days post-fertilization. (A) Image of a section through a wild-type eye at 72 hpf. (B,C) Low resolution images of sections through an embryo with an ectopic eye on the yolk at the level of the back of lens (B) and deeper into the back of the retina (C) and higher resolution images through the ectopic eye showing that the retina is still open at its ventral pole (D,F) where the retinal lamination and retinal pigmented epithelium (RPE) are discontinuous. However, in the deeper layers, the outer nuclear layer is continuous across the presumed position of fissure fusion (arrow in F). (D,E) Arrows in (D,E) indicate the choroid fissure. SC, spinal cord; EE, ectopic eye; RGC, retinal ganglion layer; ONL, outer nuclear layer. Scale bars 50 μM.

Acknowledgments

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