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Fig. S8
BCI and BCI215 do not affect cardiomyocyte proliferation or cardiac size in uninjured hearts. (A) Cryosections of uninjured hearts injected for 6 days with DMSO (n=11), BCI (n=9) or BCI215 (n=9), stained for AFOG (top) and for Mef2c and PCNA (bottom). (B) Quantification of cardiomyocyte proliferation in uninjured hearts injected with BCI, BCI215, or vehicle DMSO. (C) Graph representing the ratio of ventricle area and fish body weight (VA/BW) in samples at 8 dpa injected for 6 days with DMSO (n=12), BCI (n=6), or BCI215 (n=9), and samples at 20 dpa injected for 6 days with DMSO (n=8), BCI (n=11), or BCI215 (n=11). BCI and BCI215 compounds do not cause cardiomegaly. n.s.=not significant. One-way ANOVA. Scale bars, 100 μm.