ZFIN Image: Lovett-Barron et al., 2017, Fig. 1

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Figure Caption

Fig. 1

Variability in Sensorimotor Reaction Time Reflects the Internal State of Alertness in Larval Zebrafish

(A) Schematic of behavioral apparatus and example data. Tethered zebrafish are presented with a looming dot stimulus, and tail movements are recorded with an infrared (IR) camera. (Right) Trials in an example fish. Black dots indicate escape onset.

(B) Histogram of RTs for an example fish.

(C) Schematic of combined behavior and heart-rate monitoring with two-photon cardiac imaging in Tg(cmlc2:GFP) fish. (Right) Example two-photon images of GFP+ heart when dilated and constricted (each image is an average of six frames). White brackets indicate ventricle cross section.

(D) Example of heart-rate time series together with behavior across two trials.

(E) Summary data, n = 6. See Figure S1A for individual fish example. Solid line: linear regression; shaded region: 95% confidence interval.

See also Figure S1.

Acknowledgments

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Reprinted from Cell, 171(6), Lovett-Barron, M., Andalman, A.S., Allen, W.E., Vesuna, S., Kauvar, I., Burns, V.M., Deisseroth, K., Ancestral Circuits for the Coordinated Modulation of Brain State, 1411-1423.e17, Copyright (2017) with permission from Elsevier. Full text @ Cell