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Fig. 6
Proteinuric zebrafish model. (A) Phenotype of control (larvae injected with control MO) and nphs2 morphants at 4 days postfertilization (dpf). Nphs2 morphants develop severe late-stage pericardial edema at 4 dpf, often indicating glomerular injury of pronephros. (B) Ultrastructural alteration of 4-dpf zebrafish glomerular podocytes. (a) Controls show fine and regular podocyte foot processes (arrowheads); (b) nphs2 morphants display extensive and irregular podocyte foot processes (arrowheads). Bar (A) = 1 mm, (B) = 500 nm. C, capillary lumen; G, glomerular basement membrane; MO, morpholino antisense oligo.
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