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Fig. 8
Ventral periocular neural crest is depleted in MZ-zic2 mutants. Single confocal sections through optic cups of embryos derived from zic2agbt133/+; zic2b1116/zic2b1116 parents. A-C’: embryo with normal retinal morphology. D-F’: embryo with coloboma. Embryos were imaged in lateral mounts. Cyan = nuclei visualized by DAPI; yellow=F-actin cytoskeleton visualized by phalloidin. Arrowheads point to aberrant gap in the ventral retina (coloboma). Embryos are shown in lateral views, anterior to the right (A-C) or anterior to the left (E-G). B’, C’, E’, F’ are enlarged from B, C, E and F, respectively.
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Reprinted from Developmental Biology, 429(1), Sedykh, I., Yoon, B., Roberson, L., Moskvin, O., Dewey, C.N., Grinblat, Y., Zebrafish zic2 controls formation of periocular neural crest and choroid fissure morphogenesis, 92-104, Copyright (2017) with permission from Elsevier. Full text @ Dev. Biol.