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Fig. 2
Zebrafish Zic2 is required for craniofacial cartilage development. A: normal neurocranium and branchial arches. B: hypoplastic, disorganized craniofacial cartilages in a zic2 mutant. C: Craniofacial defects are enriched in zic2 mutants derived from double heterozygous parents. D: In embryos that lack maternal zic2b, craniofacial defects are observed in zic2 mutants and in embryos with one wildtype copy of zic2a. Cartilage was visualized by staining with Alcian Blue. Embryos at 5 dpf are shown in ventral views, anterior to the left.
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Reprinted from Developmental Biology, 429(1), Sedykh, I., Yoon, B., Roberson, L., Moskvin, O., Dewey, C.N., Grinblat, Y., Zebrafish zic2 controls formation of periocular neural crest and choroid fissure morphogenesis, 92-104, Copyright (2017) with permission from Elsevier. Full text @ Dev. Biol.