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Fig. 9
Poly I:C injection in medaka promotes scar resolution following cardiac injury.
Adult fli::GFP;gata1::GFP medaka were injected with PBS or poly I:C immediately after injury. Hearts were collected at 1 mpci, and scar composition and resolution were examined by AFOG staining. (A) Healthy muscle stained in orange, fibrin in red, and collagen in blue. Sections with the largest scar area for each heart (delineated by dotted lines) were selected and quantified (B; n ≥ 4). Scale bars, 200 μm. Scar tissue in poly I:C-exposed hearts was significantly smaller than in controls at 1 mpci.
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