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Fig. S2
Thecdh2mophenotype recapitulates the cdh2-/- phenotype; related to Figure 2. (A) Both mutant and morphant phenotypes include abnormal neural tube morphogenesis and (B) cell de-adhesion within the tailbud. Neither manipulation affects somite boundary formation as visualized by either DIC (C,D) or FN immunolocalization (E). Furthermore, both phenotypes exhibit FN formation within the mesenchymal presomitic mesoderm (F). (G) Thecdh2moalso strongly inhibits both total and stable Cdh2 as reported by the cdh2-sfGFPTagRFP transgene (n=9). Scale bar = 40 µm.
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