ZFIN Image: Ju et al., 2015, Fig. 4

Image

Figure Caption

Fig. 4

Activation of the Ras and mTOR pathways in brain tumors. (A) A 6-month-old krt5-derived brain tumor infiltrating both the ventral brain and the VZ. Tumor cells exhibited prominent expression of phospho-ERK1/2 (B) and phospho-4E-BP1 (C). (B) and (C) show immunofluorescence staining of the white framed region in (A). Note the relatively normal cerebellum exhibited much less staining for the two antibodies. (D) A 12-month-old gfap-derived brain tumor showed tumor cell infiltration of the VZ surrounding the OT. Tumor cells exhibited prominent expression of pERK1/2 (E) and pS6RP (F). Note that paraffin sections were used for immunofluorescence. Ce, cerebellum; OT, Optic tectum. Scale bars, 200 µm for A; 40 µm for B, C, D, and E.

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Mol. Cancer