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Fig. S3
Effects of different-level overexpression of gbx2 on FGF signaling in embryos. Embryos were injected with gbx2 mRNA of 5 pg/embryo (low dose) or 30 pg/embryo (high dose) and examined at the bud stage (A) or 26 hpf (B) for the expression of FGF downstream genes shown on the left. The most striking phenotypes and their proportions are shown in the respective panels. Lateral views with anterior to the top and dorsal to the right (A) or with anterior to the left and dorsal to the top (B). The positions of the MHB are marked with small triangles. Scale bars, 200 µm.
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Reprinted from Mechanisms of Development, 130(11-12), Nakayama, Y., Kikuta, H., Kanai, M., Yoshikawa, K., Kawamura, A., Kobayashi, K., Wang, Z., Khan, A., Kawakami, K., and Yamasu, K., Gbx2 functions as a transcriptional repressor to regulate the specification and morphogenesis of the mid-hindbrain junction in a dosage- and stage-dependent manner, 532-52, Copyright (2013) with permission from Elsevier. Full text @ Mech. Dev.