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Fig. S4 Midline structures are intact in NS and LS Shp2-variants. (A-C) Brightfield images of (A) WT-Shp2 control, (B) Shp2-D61G and (C) Shp2-A462T expressing embryos, showing normal notochord formation. (D-I) In situ hybridization analysis showed contiguous shh expression in the floorplate. (D-F) Composite pictures of lateral views. (G-I) Dorsal views. The number of embryos showing the depicted expression pattern/ total number of embryos is: WT-Shp2, n=20/20; Shp2-D61G, n=30/30; Shp2-A462T, n=30/30.
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