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Fig. 2 Immunocytochemical analysis of COS-1 cells transiently transfected with constructs encoding HA-tagged WT and mutant (p.Ser126Asn, p.His455Tyr) ZNF408 proteins. DAPI stains cell nuclei, whereas the anti-HA antibody stains the ZNF408 fusion proteins (indicated by arrows). (Right) Merged pictures (DAPI in blue, and HA-tagged ZNF408 proteins in red). Representative examples are shown for each transfection, indicating full nuclear localization for the WT and p.Ser126Asn ZNF408 proteins, but with the p.His455Tyr mutant ZNF408 confined mainly to the cytoplasm (each indicated by arrows).
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