ZFIN Image: Qian et al., 2013, Fig. 6

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Figure Caption

Fig. 6 Organ LR asymmetric pattern shows that Enc1l functions as a downstream effector of RA and FGF signaling. (A) Knockdown of Encl1 shows L-loop, midline, and R-loop heart at 52phf. The embryos treated with SU5402 or RA also show disrupted LR asymmetry of the heart, which can be rescued by injected with encl1 mRNA. (B) The embryos treated with SU5402 or RA show disrupted LR asymmetry of liver at 72hpf, which can be rescued by injection with encl1 mRNA. The second line is the fluorescence images that only shows the liver LR asymmetric pattern. (C) Statistical graph of the heart location and (D) Statistical graph of the liver location. L: left side; R: right side.

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Acknowledgments

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Reprinted from Developmental Biology, 374(1), Qian, M., Yao, S., Jing, L., He, J., Xiao, C., Zhang, T., Meng, W., Zhu, H., Xu, H., and Mo, X., ENC1-like Integrates the Retinoic Acid/FGF Signaling Pathways to Modulate Ciliogenesis of Kupffer's Vesicle during Zebrafish Embryonic Development, 85-95, Copyright (2013) with permission from Elsevier. Full text @ Dev. Biol.