ZFIN Image: Huang et al., 2012, Fig. S3

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Figure Caption

Fig. S3

Flk1-GFP Endothelial Cells Respond to Inhibitors in Primary Culture, Related to Figure 3 (A–L) SU5416 (5 μM) significantly inhibits endothelial proliferation and differentiation (C, bright field, and D) compared with control (A, bright field, and B) at day 5 of culture. As expected, SU5416 inhibits and bFGF promotes (H and G, bright field; and J and I, bright field) differentiation and proliferation of endothelial cells (E and F controls), respectively, but bFGF does not restore SU5416-induced blockade of endothelial growth (K and L, 50 ng/ml bFGF + 5 μM SU5416), suggesting that VEGF signaling functions independently of the bFGF pathway in endothelial cell proliferation.

Acknowledgments

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