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Fig. S3

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ZDB-IMAGE-120815-27
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Figures for Liu et al., 2012
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Fig. S3 Morpholino efficiency test and hemorrhage phenotype for integrin morphants.

(A) itgavMOf and itgavMOr primers were used to amplify integrin α v around the exonintron boundary targeted by the itgave3i3 MO. Black arrows denote the wildtype band. Stars denote misspliced new products seen only in the morphants. (B) Hemorrhages (arrow) are observed in the head of itgavATG morphants between 50 – 52 hpf. (C) itgb8MOf and itgb8MOr primers were used to amplify integrin β 8 around the exonintron boundary targeted by both itgb8e2i2 and itgb8e2i1 morpholinos. Black arrows denote the wildtype band, while a star denotes misspliced new products seen only in the morphants. (D) Hemorrhages (arrow) are observed in the head of itgb8e2i1 morphants.

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Reprinted from Developmental Biology, 363(1), Liu, J., Zeng, L., Kennedy, R.M., Gruenig, N.M., and Childs, S.J., betaPix plays a dual role in cerebral vascular stability and angiogenesis, and interacts with integrin alphavbeta8, 95-105, Copyright (2012) with permission from Elsevier. Full text @ Dev. Biol.