ZFIN Image: Zou et al., 2012, Fig. S4

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Figure Caption

Fig. S4

The aggregating patterns and cell shapes were influenced by the number of participating Crb2b-expressing transgenic cells in the crb2a^m289 mutant embryos, related to Figure 5.

A. Three transgenic cells in the leftmost panel were magnified to better reveal their morphologies. The two cells above an actin-rich block of neuronal processes adhered to each other and established a flat adhering interface, which was enriched with Crb2a and actin compared to the rest of the cell membranes (arrows, the contour drawing). The bottom transgenic cell appeared to be prevented from adhering with the upper two cells by the block of neuronal processes. B. A mini rosette was formed by four Crb2b-expressing transgenic cells, which were also Zpr1 positive. These cells were wedge-shaped and adhered to each other at their pointed ends in the center of the aggregate, where Crb2a was enriched (arrows, the contour drawing).

Acknowledgments

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Reprinted from Developmental Cell, 22(6), Zou, J., Wang, X., and Wei, X., Crb Apical Polarity Proteins Maintain Zebrafish Retinal Cone Mosaics via Intercellular Binding of Their Extracellular Domains, 1261-1274, Copyright (2012) with permission from Elsevier. Full text @ Dev. Cell