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Figure Caption
Fig. 3
Transgene expression in TCFsiam transgenics is highly regulated by lef1. All images (A–D) show a representative 48 hpf larva. Expression analysis of the Tg(7xTCF-Xla.Siam:GFP)ia4 reporter in lef1/sinf U767 homozygous mutants (B) is significantly reduced in several tissues, when compared to age matched Tg(7xTCF-Xla.Siam:GFP)ia4 fish (A). In tcf7l1am881/m881 (hdl) (C) and tcf7l2zf55/zf55 (D) no significant differences can be observed in respect to A. Anterior is shown to the left. Hb: habenula; hy:hypothalamus; t.tectum; pf: pectoral fin; jc: jaw cartilages; MHB: midbrain-hindbrain boundary; h: heart.
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Reprinted from Developmental Biology, 366(2), Moro, E., Özhan, G., Mongera, A., Beis, D., Wierzbicki, C., Young, R.M., Bournele, D., Domenichini, A., Valdivia, L.E., Lum, L., Chen, C., Amatruda, J.F., Tiso, N., Weidinger, G., and Argenton, F., In vivo Wnt signaling tracing through a transgenic biosensor fish reveals novel activity domains, 327-340, Copyright (2012) with permission from Elsevier. Full text @ Dev. Biol.