ZFIN Image: Sorrell et al., 2011, Fig. 4

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Figure Caption

Fig. 4

Increased Fgf signaling induces cardiac progenitor marker expression throughout the anterior LPM. Expression of nkx2.5 (A,B), nkx2.5 and ntla (C,D), hey2 (E,F), tal1 (G,H) and etv2 (I,J) in control and Tg(hsp70:ca-fgfr1)^pd3 embryos heat-shocked at the TB stage. Increased Fgf signaling controls an inverse relationship between the cardiac and hematovascular progenitor markers in the anterior LPM. Increased Fgf at the TB stage signaling dramatically induces the expression of nkx2.5 and hey2 (B,F) in the anterior LPM compared to non-transgenic control siblings (A,E) at 8s. (D) nkx2.5 (arrows) is induced ectopically and precociously at the 3s when Fgf signaling is increased. Increased Fgf signaling at TB reduced the expression of the hematovascular markers tal1 and etv2 in the anterior LPM (arrows in H,J) compared to non-transgenic control siblings (arrow in G,I) at 8s. All views are dorsal with anterior up.

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Reprinted from Developmental Biology, 358(1), Sorrell, M.R., and Waxman, J.S., Restraint of Fgf8 signaling by retinoic acid signaling is required for proper heart and forelimb formation, 44-55, Copyright (2011) with permission from Elsevier. Full text @ Dev. Biol.