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Fig. 6
The small-molecular inhibitor of VEGFR2 inhibiting the tumor growth and neovascularization.
(A–C) The imaging showed the obvious blockage of the specific inhibitor of VEGFR2, SU5416 (2 µM), to the neovascularization (A), tumor growth (B), and normal vascular vessels of zebrafish (C). (D,E) The quantitative analysis of the inhibiting effects of SU5416 to neovascularization (D) and tumor growth (E). (F) The result of MTT assay for B16 cells that treated by SU5416 for 48 hours in vitro at a concentration of 0, 1, 2 μM. Scale bar, 100 μm.
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