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Fig. S1 Additional morpholinos cause Tp53-dependent boundary domain expansion. Embryos injected with control (A–C), tcf3b (D), deltaA (E), rfng (F), tcf3b + tp53 (G), deltaA + tp53 (H), and rfng + tp53 (I) morpholinos, and hybridized with probe to boundary marker rfng. Tcf3b, deltaA, and rfng MOs alone induce an expansion of rfng expression (compare A–C with D–F), that is rescued when tp53 MO is co-injected (compare D–F with G–I).
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Reprinted from Developmental Biology, 350(2), Gerety, S.S., and Wilkinson, D.G., Morpholino artifacts provide pitfalls and reveal a novel role for pro-apoptotic genes in hindbrain boundary development, 279-289, Copyright (2011) with permission from Elsevier. Full text @ Dev. Biol.