ZFIN Image: Roberts et al., 2009, Fig. 6

Image

Figure Caption

Fig. 6 Loss of protein kinase C, iota (PrkCi) function causes formation of excess oligodendrocyte progenitor cells (OPCs) from pMN precursors. Panels show frames captured from time-lapse videos of wild-type and has^-/- embryos carrying the Tg(olig2:egfp) reporter. Dorsal is up and time elapsed from beginning of imaging at 50 hours postfertilization (hpf) is indicated in upper right corners of panels. Brackets mark pMN precursor domain in ventral spinal cord. A: Wild-type embryo. Arrowheads mark OPCs migrating dorsally from the ventral pMN precursor domain. B: has^-/- embryo. More OPCs (arrowheads) emerge from the pMN domain than in wild-type over a similar period of time. C: Quantification of dorsally migrating OPCs. Data were obtained from time-lapse movies of 6 wild-type and 5 has^-/- embryos. Error bars represent SEM. Statistical significance was determined using Student′s t-test.

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Dev. Dyn.