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Fig. S2
Nitric Oxide mediates the effect of blood flow on HSCs.
(A-I) Effect of chemical modifiers of blood flow on vascular diameter in vivo. Transgenic fli:GFP fish were treated with chemicals (10 μM) from 10 somites to 36 hpf and imaged by confocal microscopy. Microscopy images with measurement of the diameter of the dorsal aorta in representative samples of drug-treated embryos. The inset shows a lower magnification image to visualize the entire tail region. The red bars indicate the width of the dorsal aorta.
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Reprinted from Cell, 137(4), North, T.E., Goessling, W., Peeters, M., Li, P., Ceol, C., Lord, A.M., Weber, G.J., Harris, J., Cutting, C.C., Huang, P., Dzierzak, E., and Zon, L.I., Hematopoietic stem cell development is dependent on blood flow, 736-748, Copyright (2009) with permission from Elsevier. Full text @ Cell