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Fig. 2 A new transgenic line allows temporal cell-autonomous activation of Bmp signaling. (A) Schematic diagram of construct used to create the new line. A multimerized minimal heat shock-responsive promoter is flanked by genes for GFP and a constitutively active mutant form of the Type Ib Bmp receptor. Tol2 elements enhance transgenesis efficiency. (B) Early heat shock of a transgenic embryo at dome stage recapitulates the expected Bmp ventralized phenotype. (C) eve1 expression is rapidly induced by ectopic Bmp signaling. Embryos were heat-shocked at dome stage and fixed at shield stage.
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Reprinted from Developmental Biology, 329(1), Row, R., and Kimelman, D., Bmp inhibition is necessary for post-gastrulation patterning and morphogenesis of the zebrafish tailbud, 55-63, Copyright (2009) with permission from Elsevier. Full text @ Dev. Biol.