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Fig. 6 ptc expression in syu homozygotes. Transcripts were revealed by in situ hybridisation with antisense RNA probes to ptc1 (A and C) or ptc2 (B and D) on 18–20 somite embryos. Mutations homozygous for syu have a dramatic reduction in ptc1 expression (C and cf. A, which shows wild-type ptc1 expression), but hardly any reduction in ptc2 expression (D and cf. B, which shows wild-type ptc2 expression).
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Reprinted from Developmental Biology, 208, Lewis, K.E., Concordet, J.P., and Ingham, P.W., Characterisation of a second patched gene in the zebrafish Danio rerio and the differential response of patched genes to hedgehog signalling, 14-29, Copyright (1999) with permission from Elsevier. Full text @ Dev. Biol.