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Fig. 4 Activity of fgfr1 is transiently required for rhombomere patterning. Dorsal view and lateral view of wild-type (A–C, G–J) and fgfr1hdf (D–F, K–N) embryos. At st. 18, krox20 expression in the r5 is lost in the mutant, whereas the expression in r3 is not affected (A, D). The expression in r5 is restoring at st. 20 in the mutant (B, E), and is recovered at st. 22 (C, F). The expression of pax6 in forebrain and hindbrain is normal in the mutant (G, H, K, L). The expression of pax2 in MHB (I, M) and shh in prechordal plate and floor plate (J, N) are not affected in the mutant.
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Reprinted from Developmental Biology, 304(1), Yokoi, H., Shimada, A., Carl, M., Takashima, S., Kobayashi, D., Narita, T., Jindo, T., Kimura, T., Kitagawa, T., Kage, T., Sawada, A., Naruse, K., Asakawa, S., Shimizu, N., Mitani, H., Shima, A., Tsutsumi, M., Hori, H., Wittbrodt, J., Saga, Y., Ishikawa, Y., Araki, K., and Takeda, H., Mutant analyses reveal different functions of fgfr1 in medaka and zebrafish despite conserved ligand-receptor relationships, 326-337, Copyright (2007) with permission from Elsevier. Full text @ Dev. Biol.