Examples of Mutants with Photoreceptor Degeneration. WT and mutant retinas (A-H, mtis113; I and J, ssds386) were sectioned and stained with DAPI (A, B, E, F, and I) and zpr1 monoclonal antibody (double-cone photoreceptor marker) (C, D, G, H, and J). At 7 dpf, photoreceptors in the central part of the retina have degenerated in both mti (A-D) and ssd (I-J). In the mti retina at 14 dpf, degeneration has spread to the inner nuclear layer (INL). Arrows show the ciliary marginal zone, from which new cells are continually added to the growing retina. Scale bar is 100 μm. (K) Mutants with photoreceptor degeneration may (mtis113) or may not (ssds386) be dark in VBA assay. Scale bar is 1 mm.
This image is the copyrighted work of the attributed author or publisher, and
ZFIN has permission only to display this image to its users.
Additional permissions should be obtained from the applicable author or publisher of the image.
Full text @ PLoS Genet.