ZFIN ID: ZDB-GENE-991207-24
Gene Name: catenin (cadherin-associated protein), alpha 1
Gene Symbol: ctnna1    Nomenclature History

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Previous Names: ctnna, dan[a]E, [a]E-catenin (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 24 Mapping Details/Browsers
Description: Exhibits actin filament binding activity and cadherin binding activity. Involved in tissue homeostasis. Localizes to several cellular components, including adherens junction; catenin complex; and microvillus. Human ortholog(s) of this gene implicated in patterned macular dystrophy 2. Orthologous to human CTNNA1 (catenin alpha 1).
Genome Resources: Alliance (1),  Gene:30741 (1),  Ensembl(GRCz11):ENSDARG00000102441 (1)
GENE EXPRESSION
All Expression Data: 2 figures from 2 publications
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2004 [MGC:76830]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Hatching:Pec-fin (60.0h-72.0h)
 
High Throughput Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
ct3aGt Transgenic Insertion Unknown Unknown DNA
hu10414 Small Deletion Unknown Frameshift, Premature Stop TALEN
la014591Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa24534 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa39460 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-ctnna1 N/A 1
    MO2-ctnna1 N/A 2
    TALEN1-ctnna1 1
    DISEASE ASSOCIATED WITH ctnna1 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    patterned macular dystrophy 2 Alliance Macular dystrophy, patterned, 2 608970
    DISEASE ASSOCIATED WITH ctnna1 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process tissue homeostasis (more)
    Cellular Component adherens junction (more)
    Molecular Function actin filament binding (more)
    GO Terms (all 11)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA ctnna1-201 (1)    Ensembl 3734
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM ctnna1
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(kdrl:ctnna-EGFP) kdrl ctnna1EGFP Danio rerio 1 4
    MARKER RELATIONSHIPS
    ctnna1 Contained in: [BAC] CH211-214P17 (1), CH211-271O13 (1), DKEYP-36H4 (1)
    [Fosmid] ZFOS-887A5 (1)
    ctnna1 Encodes: [cDNA] MGC:76830 (1), MGC:175043 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_131456 (1) 3777 nt
    Genomic GenBank:CU681852 (1) 198109 nt
    Select Tool
    Polypeptide UniProtKB:A9JRW0 (1) 907 aa
    Sequence Information (all 18)
    ORTHOLOGY for ctnna1 ( Chr: 24 )
    CITATIONS (51)