ZFIN ID: ZDB-GENE-991124-7
Gene Name: T-box 5a
Gene Symbol: tbx5a
Sequence Ontology ID : SO:0000704

{{control.fieldName}} Edit

ID: {{control.nomenID}}
{{control.fieldName}}:
Reason:
Comments:

Attributions

{{pub.zdbID}}
Previous Names: tbx5.1, tbx5, zf-tbx5, zTbx5, etID310031.5 (1), heartstrings, hst

Add new Alias

Alias
Attribution

Attributions for Alias: {{control.newAlias}}

{{pub.zdbID}}

Delete Alias:

(Including Attributions)
Location: Chr: 5 Mapping Details/Browsers
Nomenclature History
AUTOMATED DESCRIPTION
Exhibits DNA-binding activity transcription factor activity, RNA polymerase II repressing transcription factor binding activity, and sequence-specific DNA binding activity; involved in several  ...
GENE EXPRESSION
All Expression Data: 142 figures from 83 publications
Directly Submitted Expression Data: 6 figures (14 images) from Thisse et al., 2005 [eu790]
Wild-type Stages, Structures: Gastrula:Bud (10.0h-10.33h) to Adult (90d-730d, breeding adult)
 
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
m21 Point Mutation Unknown Premature Stop ENU
tpl58Gt Transgenic Insertion Unknown Unknown DNA
Targeting reagents:
PHENOTYPE
Data: 45 figures from 20 publications
Observed in:
DISEASE ASSOCIATED WITH tbx5a HUMAN ORTHOLOG
Disease Ontology Term OMIM Term OMIM Phenotype ID
Holt-Oram syndrome Holt-Oram syndrome 142900
GENE ONTOLOGY
Ontology GO Term
Biological Process positive regulation of transcription by RNA polymerase II (more)
Cellular Component nucleus (more)
Molecular Function DNA-binding transcription factor activity (more)
GO Terms (all 36)
PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR001699 (1)
  • InterPro:IPR008967 (1)
  • InterPro:IPR018186 (1)
  • InterPro:IPR036960 (1)
  • PROSITE:PS01264 (1)
  • PROSITE:PS01283 (1)
  • PROSITE:PS50252 (1)
  • Pfam:PF00907 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA tbx5a-001 (1) 2059
    ncRNA tbx5a-002 (1) 768
    GENE PRODUCT DESCRIPTION
    INTERACTIONS AND PATHWAYS
    tbx5a interacts with
    ANTIBODIESNo data available
    PLASMIDS
    Addgene
    CONSTRUCTS WITH SEQUENCES FROM tbx5a
    MARKER RELATIONSHIPS
    tbx5aContained in: [BAC] CH211-245E21 (1) (order this)
    tbx5aEncodes: [EST] eu790 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_130915 (1) 2590bp
    Genomic GenBank:CU181811 (1) 144158bp
    Select Tool
    Polypeptide UniProtKB:Q9IAK8 (1) 492aa
    Sequence Clusters UniGene:81302 (1)
    Sequence Information (all 18)
    OTHER tbx5a GENE PAGES
  • Alliance (1)
  • Gene:30071 (1)
  • VEGA:OTTDARG00000029274 (1)
  • Ensembl(GRCz11):ENSDARG00000024894 (1)
  • ORTHOLOGY for tbx5a (Chr: 5)
    CITATIONS (181)