Gene

tbx5a

ID
ZDB-GENE-991124-7
Name
T-box transcription factor 5a
Symbol
tbx5a Nomenclature History
Previous Names
  • tbx5.1
  • tbx5
  • zf-tbx5
  • zTbx5
  • etID310031.5 (1)
  • heartstrings
  • hst
Type
protein_coding_gene
Location
Chr: 5 Mapping Details/Browsers
Description
Exhibits DNA-binding transcription factor activity; RNA polymerase II repressing transcription factor binding activity; and sequence-specific DNA binding activity. Involved in several processes, including cardiac muscle tissue regeneration; heart development; and limb development. Localizes to actin cytoskeleton and nucleus. Is expressed in several structures, including eye; immature eye; mesoderm; pectoral fin; and pericardial region. Used to study Holt-Oram syndrome. Human ortholog(s) of this gene implicated in Holt-Oram syndrome. Orthologous to human TBX5 (T-box transcription factor 5).
Genome Resources
Note
None
Expression
All Expression Data
144 figures from 86 publications
Cross-Species Comparison
High Throughput Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
51 figures from 23 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With tbx5a Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Holt-Oram syndrome Alliance Holt-Oram syndrome 142900
Associated With tbx5a Via Experimental Models
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR018186 Transcription factor, T-box, conserved site
Family IPR001699 Transcription factor, T-box
Homologous_superfamily IPR008967 p53-like transcription factor, DNA-binding
Homologous_superfamily IPR036960 T-box superfamily
Domain Details Per Protein
Protein Length p53-like transcription factor, DNA-binding T-box superfamily Transcription factor, T-box Transcription factor, T-box, conserved site
UniProtKB:Q9IAK8 492
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations