Gene

tbx4

ID
ZDB-GENE-991124-5
Name
T-box transcription factor 4
Symbol
tbx4 Nomenclature History
Previous Names
  • zTbx4
  • pelvic finless (1)
  • pfl (1)
  • unm_zf358
  • zf-tbx4
Type
protein_coding_gene
Location
Chr: 15 Mapping Details/Browsers
Description
Predicted to have DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in embryonic hindlimb morphogenesis and embryonic pelvic fin morphogenesis. Predicted to localize to nucleus. Is expressed in diencephalon; mesoderm pelvic fin bud; pelvic fin bud; presumptive neural retina; and retina. Human ortholog(s) of this gene implicated in ischiocoxopodopatellar syndrome. Orthologous to human TBX4 (T-box transcription factor 4).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
4 figures from 3 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
11 figures from 3 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With tbx4 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
ischiocoxopodopatellar syndrome Alliance Ischiocoxopodopatellar syndrome with or without pulmonary arterial hypertension 147891
Amelia, posterior, with pelvic and pulmonary hypoplasia syndrome 601360
Associated With tbx4 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR018186 Transcription factor, T-box, conserved site
Family IPR001699 Transcription factor, T-box
Homologous_superfamily IPR008967 p53-like transcription factor, DNA-binding
Homologous_superfamily IPR036960 T-box superfamily
Domain Details Per Protein
Protein Length p53-like transcription factor, DNA-binding T-box superfamily Transcription factor, T-box Transcription factor, T-box, conserved site
UniProtKB:B3DGX3 543
UniProtKB:F1R688 543
UniProtKB:Q9PUS8 87
UniProtKB:Q9IAK9 543
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations