ZFIN ID: ZDB-GENE-991123-8
Gene Name: parathyroid hormone 1 receptor
Gene Symbol: pth1r    Nomenclature History

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Previous Names: pth1ra, pthr1, zPTH1R

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 2 Mapping Details/Browsers
Description: Exhibits parathyroid hormone receptor activity and peptide hormone binding activity. Involved in dorsal aorta development and positive regulation of inositol phosphate biosynthetic process. Predicted to localize to the integral component of membrane. Human ortholog(s) of this gene implicated in Jansen's metaphyseal chondrodysplasia; chondrodysplasia Blomstrand type; osteochondrodysplasia; and primary failure of tooth eruption. Is expressed in several structures, including bone tissue; gill; liver; opercular flap; and pleuroperitoneal region. Orthologous to human PTH1R (parathyroid hormone 1 receptor).
Genome Resources: Alliance (1),  Gene:30629 (1),  Ensembl(GRCz11):ENSDARG00000020957 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Sequence Targeting Reagents
Targeting Reagent Created Alleles Publications
MO1-pth1r N/A 1
MO2-pth1r N/A 1
DISEASE ASSOCIATED WITH pth1r HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
chondrodysplasia Blomstrand type Alliance Chondrodysplasia, Blomstrand type 215045
Jansen's metaphyseal chondrodysplasia Alliance Metaphyseal chondrodysplasia, Murk Jansen type 156400
primary failure of tooth eruption Alliance Failure of tooth eruption, primary 125350
Eiken syndrome 600002
DISEASE ASSOCIATED WITH pth1r VIA EXPERIMENTAL MODELS No data available
PROTEIN FAMILIES, DOMAINS AND SITES
Type InterPro ID Name
Family IPR000832 GPCR, family 2, secretin-like
Domain IPR001879 GPCR, family 2, extracellular hormone receptor domain
Family IPR002170 GPCR, family 2, parathyroid hormone receptor
Domain IPR017981 GPCR, family 2-like
Conserved_site IPR017983 GPCR, family 2, secretin-like, conserved site
Homologous_superfamily IPR036445 GPCR family 2, extracellular hormone receptor domain superfamily
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA pth1ra-202 (1)    Ensembl 1890
Browsers: UCSCNCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM pth1r No data available
MARKER RELATIONSHIPS
pth1r Contained in: [BAC] CH73-359K10 (1), CH211-163F10 (1), CH211-178J16 (1)
pth1r Encodes: [cDNA] MGC:193749 (1), MGC:193760 (1)
SEQUENCE INFORMATION
Type Accession # Length (bp/aa) Analysis
RNA RefSeq:NM_131357 (1) 2129 bp
Genomic GenBank:AL929518 (1) 162473 bp
Select Tool
Polypeptide UniProtKB:Q9PVD3 (1) 536 aa
Sequence Clusters UniGene:81300 (1)
Sequence Information (all 24)
ORTHOLOGY for pth1r ( Chr: 2 )
CITATIONS (33)