ZFIN is now using GRCz12tu for Genomic Data
Gene
pth3r
- ID
- ZDB-GENE-991123-12
- Name
- parathyroid hormone 3 receptor
- Symbol
- pth3r Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 12 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Enables parathyroid hormone receptor activity and peptide hormone binding activity. Predicted to be involved in adenylate cyclase-modulating G protein-coupled receptor signaling pathway. Predicted to act upstream of or within G protein-coupled receptor signaling pathway and cell surface receptor signaling pathway. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in bone tissue; gill; liver; muscle; and pleuroperitoneal region.
- Genome Resources
- Note
-
Evidence from two papers, Pinheiro et al. (2012) and Bhattacharya et al. (2011) shows that after the 2 rounds of vertebrate genome duplication, three PTH receptors existed, pth1r, pth2r, and pth3r. zfish lineage kept 1r, 2r, and 3r. Human lineage lost 3r, kept 1r and 2r.
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR017983 | GPCR, family 2, secretin-like, conserved site |
| Domain | IPR001879 | GPCR, family 2, extracellular hormone receptor domain |
| Domain | IPR017981 | GPCR, family 2-like, 7TM |
| Family | IPR000832 | GPCR, family 2, secretin-like |
| Family | IPR002170 | GPCR, family 2, parathyroid hormone receptor |
| Family | IPR050332 | G-protein coupled receptor 2 |
| Homologous_superfamily | IPR036445 | GPCR family 2, extracellular hormone receptor domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | GPCR, family 2, extracellular hormone receptor domain | GPCR family 2, extracellular hormone receptor domain superfamily | GPCR, family 2-like, 7TM | GPCR, family 2, parathyroid hormone receptor | GPCR, family 2, secretin-like | GPCR, family 2, secretin-like, conserved site | G-protein coupled receptor 2 |
|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q9PVD2 | InterPro | 542 | |||||||
| UniProtKB:A0A8M9QMD4 | InterPro | 315 |
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
pth1rb-201
(1)
|
Ensembl | 2,143 nt |
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers