Gene

pth3r

ID
ZDB-GENE-991123-12
Name
parathyroid hormone 3 receptor
Symbol
pth3r Nomenclature History
Previous Names
  • pth1rb (2)
  • pthr3
  • zPTH3R (1)
Type
protein_coding_gene
Location
Chr: 12 Mapping Details/Browsers
Description
Exhibits parathyroid hormone receptor activity and peptide hormone binding activity. Predicted to be involved in adenylate cyclase-modulating G protein-coupled receptor signaling pathway. Predicted to localize to plasma membrane. Is expressed in bone tissue; gill; liver; muscle; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in Eiken syndrome; Jansen's metaphyseal chondrodysplasia; chondrodysplasia Blomstrand type; osteochondrodysplasia; and primary failure of tooth eruption. Orthologous to human PTH1R (parathyroid hormone 1 receptor).
Genome Resources
Note
Evidence from two papers, Pinheiro et al. (2012) and Bhattacharya et al. (2011) shows that after the 2 rounds of vertebrate genome duplication, three PTH receptors existed, pth1r, pth2r, and pth3r. zfish lineage kept 1r, 2r, and 3r. Human lineage lost 3r, kept 1r and 2r.
Comparative Information
Expression
All Expression Data
2 figures from 2 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With pth3r Human Ortholog
No data available
Associated With pth3r Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR017983 GPCR, family 2, secretin-like, conserved site
Domain IPR001879 GPCR, family 2, extracellular hormone receptor domain
Domain IPR017981 GPCR, family 2-like
Family IPR000832 GPCR, family 2, secretin-like
Family IPR002170 GPCR, family 2, parathyroid hormone receptor
Homologous_superfamily IPR036445 GPCR family 2, extracellular hormone receptor domain superfamily
Domain Details Per Protein
Protein Length GPCR, family 2, extracellular hormone receptor domain GPCR family 2, extracellular hormone receptor domain superfamily GPCR, family 2-like GPCR, family 2, parathyroid hormone receptor GPCR, family 2, secretin-like GPCR, family 2, secretin-like, conserved site
UniProtKB:Q9PVD2 542
UniProtKB:F1QGZ1 542
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations