ZFIN ID: ZDB-GENE-991119-2
Gene Name: crystallin, alpha B, a
Gene Symbol: cryaba    Nomenclature History

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Previous Names: cryab, hspb5 (1), hspb5a (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 15 Mapping Details/Browsers
Description: Exhibits unfolded protein binding activity. Involved in several processes, including heart contraction; myofibril assembly; and skeletal muscle tissue development. Localizes to the plasma membrane. Human ortholog(s) of this gene implicated in cataract 16 multiple types; dilated cardiomyopathy 1II; fatal infantile hypertonic myofibrillar myopathy; and myofibrillar myopathy 2. Is expressed in several structures, including eye; heart; otic vesicle; presumptive neural retina; and solid lens vesicle. Orthologous to human CRYAB (crystallin alpha B).
Genome Resources: Alliance (1),  Gene:30393 (1),  Ensembl(GRCz11):ENSDARG00000042621 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
vu612 Small Deletion Unknown Unknown CRISPR
Sequence Targeting Reagents
Targeting Reagent Created Alleles Publications
CRISPR1-cryaba 1
CRISPR2-cryaba 1
CRISPR3-cryaba 1
CRISPR4-cryaba 1
MO1-cryaba N/A 1
MO2-cryaba N/A 1
MO3-cryaba N/A 1
DISEASE ASSOCIATED WITH cryaba HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
cataract 16 multiple types Alliance Cataract 16, multiple types 613763
dilated cardiomyopathy 1II Alliance Cardiomyopathy, dilated, 1II 615184
fatal infantile hypertonic myofibrillar myopathy Alliance Myopathy, myofibrillar, fatal infantile hypertonic, alpha-B crystallin-related 613869
myofibrillar myopathy 2 Alliance Myopathy, myofibrillar, 2 608810
DISEASE ASSOCIATED WITH cryaba VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process heart contraction (more)
Cellular Component plasma membrane (more)
Molecular Function unfolded protein binding (more)
GO Terms (all 8)
PROTEIN FAMILIES, DOMAINS AND SITES
Type InterPro ID Name
Family IPR001436 Alpha crystallin/Heat shock protein
Domain IPR002068 Alpha crystallin/Hsp20 domain
Domain IPR003090 Alpha-crystallin, N-terminal
Homologous_superfamily IPR008978 HSP20-like chaperone
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA cryaba-201 (1)    Ensembl 1335
Browsers: UCSCNCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
CONSTRUCTS WITH SEQUENCES FROM cryaba No data available
MARKER RELATIONSHIPS
cryaba Contained in: [BAC] CH211-262M14 (1)
cryaba Encodes: [EST] af159089
[cDNA] MGC:193708 (1), MGC:193741 (1)
SEQUENCE INFORMATION
Type Accession # Length (bp/aa) Analysis
RNA RefSeq:NM_131157 (1) 900 bp
Genomic GenBank:CR385077 (1) 105764 bp
Select Tool
Polypeptide UniProtKB:Q9PUR2 (1) 168 aa
Sequence Information (all 15)
ORTHOLOGY for cryaba ( Chr: 15 )
CITATIONS (39)