ZFIN ID: ZDB-GENE-991117-1
Gene Name: glycine receptor, alpha 1
Gene Symbol: glra1    Nomenclature History

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Previous Names: [a]Z1 (1), GlyR [a]Z1 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 14 Mapping Details/Browsers
Description: Exhibits extracellularly glycine-gated chloride channel activity and glycine binding activity. Predicted to contribute to chloride channel activity. Involved in ion transport; nervous system development; and response to amino acid. Localizes to integral component of membrane. Is expressed in brain; hindbrain; and spinal cord. Used to study hyperekplexia. Human ortholog(s) of this gene implicated in hyperekplexia 1. Orthologous to human GLRA1 (glycine receptor alpha 1).
Genome Resources: Alliance (1),  Gene:30676 (1),  Ensembl(GRCz11):ENSDARG00000012019 (1)
GENE EXPRESSION
All Expression Data: 13 figures from 9 publications
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Adult (90d-730d, breeding adult)
 
High Throughput Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa42393 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa42394 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • udm105 Small Deletion Unknown Unknown CRISPR
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-glra1 1
    MO1-glra1 N/A 1
    MO2-glra1 N/A 1
    MO3-glra1 N/A 1
    MO4-glra1 N/A 1
    DISEASE ASSOCIATED WITH glra1 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    hyperekplexia 1 Alliance Hyperekplexia 1 149400
    DISEASE ASSOCIATED WITH glra1 VIA EXPERIMENTAL MODELS
    Human Disease Fish Conditions Citations
    hyperekplexia glra1udm105/udm105 standard conditions Samarut et al., 2019
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process ion transport (more)
    Cellular Component integral component of membrane (more)
    Molecular Function extracellularly glycine-gated chloride channel activity (more)
    GO Terms (all 39)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA glra1-203 (1)    Ensembl 8401
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM glra1 No data available
    MARKER RELATIONSHIPS
    glra1 Contained in: [BAC] DKEY-97O1 (1) (order this)
    glra1 Encodes: [cDNA] MGC:194378 (1), MGC:194391 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_131402 (1) 1628 nt
    Genomic GenBank:BX640507 (1) 189019 nt
    Select Tool
    Polypeptide UniProtKB:G1K2K7 (1) 459 aa
    Sequence Information (all 29)
    ORTHOLOGY for glra1 ( Chr: 14 )
    CITATIONS (44)