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ZIRC
ZFIN ID: ZDB-GENE-991110-10
Gene Name: transcription factor 7 like 1b
Gene Symbol: tcf7l1b    Nomenclature History

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Previous Name: tcf3b (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 8 Mapping Details/Browsers
Description: Predicted to have beta-catenin binding activity; sequence-specific DNA binding activity; and transcription regulatory region DNA binding activity. Involved in several processes, including cell proliferation in dorsal spinal cord; endothelial cell fate specification; and nervous system development. Predicted to localize to the nucleus and transcription factor complex. Is expressed in nervous system; optic vesicle; and posterior neural tube. Orthologous to human TCF7L1 (transcription factor 7 like 1).
Genome Resources: Alliance (1),  Gene:30556 (1),  Ensembl(GRCz11):ENSDARG00000007369 (2)
GENE EXPRESSION
All Expression Data: 8 figures from 7 publications
Wild-type Stages, Structures: Segmentation:5-9 somites (11.66h-14.0h) to Hatching:Long-pec (48.0h-60.0h)
 
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
ihb315 Small Deletion Exon 1 Unknown CRISPR
la026648Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • zf157Tg Transgenic Insertion Unknown Unknown DNA
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-tcf7l1b 1
    MO1-tcf7l1b N/A 12
    MO3-tcf7l1b N/A 2
    MO4-tcf7l1b N/A 1
    MO5-tcf7l1b N/A 1
    DISEASE ASSOCIATED WITH tcf7l1b HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH tcf7l1b VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process cell proliferation in dorsal spinal cord (more)
    Cellular Component nucleus (more)
    Molecular Function DNA-binding transcription factor activity, RNA polymerase II-specific (more)
    GO Terms (all 23)
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA tcf7l1b-202 (1)    Ensembl 3042
    tcf7l1b-203 (1)    Ensembl 1040
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM tcf7l1b No data available
    MARKER RELATIONSHIPS
    tcf7l1b Contained in: [BAC] CH73-233G2 (1) (order this), CH211-155H12 (1) (order this)
    [Fosmid] CH1073-354H10 (1) (order this), CH1073-360A7 (1) (order this), CH1073-459D16 (1) (order this), CH1073-467B24 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_131296 (1) 3742 bp
    Genomic GenBank:BX005248 (1) 185135 bp
    Select Tool
    Polypeptide UniProtKB:A0A2R8RLK6 (1) 585 aa
    Sequence Clusters UniGene:8108 (1)
    Sequence Information (all 25)
    ORTHOLOGY for tcf7l1b ( Chr: 8 )
    CITATIONS (51)