Gene

tbx2a

ID
ZDB-GENE-990917-4
Name
T-box transcription factor 2a
Symbol
tbx2a Nomenclature History
Previous Names
  • tbx-a
  • tbxa
  • zgc:85705
Type
protein_coding_gene
Location
Chr: 5 Mapping Details/Browsers
Description
Predicted to have DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II activating transcription factor binding activity; and RNA polymerase II regulatory region sequence-specific DNA binding activity. Involved in animal organ development and pharyngeal system development. Predicted to localize to nucleus. Human ortholog(s) of this gene implicated in vertebral anomalies and variable endocrine and T-cell dysfunction. Is expressed in several structures, including digestive system; mesoderm; nervous system; pericardial region; and pronephros. Orthologous to human TBX2 (T-box transcription factor 2).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
21 figures from 9 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
8 figures from 5 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With tbx2a Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
vertebral anomalies and variable endocrine and T-cell dysfunction Alliance Vertebral anomalies and variable endocrine and T-cell dysfunction 618223
Associated With tbx2a Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR018186 Transcription factor, T-box, conserved site
Domain IPR022582 Transcription factor, T-box, region of unknown function
Family IPR001699 Transcription factor, T-box
Family IPR002070 Transcription factor, Brachyury
Homologous_superfamily IPR008967 p53-like transcription factor, DNA-binding
Homologous_superfamily IPR036960 T-box superfamily
Domain Details Per Protein
Protein Length p53-like transcription factor, DNA-binding T-box superfamily Transcription factor, Brachyury Transcription factor, T-box Transcription factor, T-box, conserved site Transcription factor, T-box, region of unknown function
UniProtKB:A0A2R8PW40 676
UniProtKB:B0R122 686
UniProtKB:Q6NV02 676
UniProtKB:A7MCH8 287
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations