Gene

skia

ID
ZDB-GENE-990715-9
Name
v-ski avian sarcoma viral oncogene homolog a
Symbol
skia Nomenclature History
Previous Names
  • skiA
  • id:ibd1250
Type
protein_coding_gene
Location
Chr: 8 Mapping Details/Browsers
Description
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and SMAD binding activity. Acts upstream of or within several processes, including cardiac conduction; cartilage development; and heart looping. Located in nucleus. Is expressed in several structures, including brain; lens; presumptive diencephalon; solid lens vesicle; and tail bud. Used to study craniosynostosis. Orthologous to human SKI (SKI proto-oncogene).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
7 figures from 2 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
1 Figure from Doyle et al., 2012
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With skia Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
craniosynostosis Alliance Shprintzen-Goldberg syndrome 182212
Associated With skia Via Experimental Models
Human Disease Fish Conditions Citations
craniosynostosis WT + MO2-skia standard conditions Doyle et al., 2012
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR003380 SKI/SNO/DAC domain
Domain IPR014890 c-SKI SMAD4-binding domain
Family IPR023216 Transcription regulator SKI/SnoN
Family IPR028760 Ski oncogene
Homologous_superfamily IPR009061 Putative DNA-binding domain superfamily
Homologous_superfamily IPR010919 SAND-like domain superfamily
Homologous_superfamily IPR037000 Ski-like, DNA-binding domain superfamily
Domain Details Per Protein
Protein Length c-SKI SMAD4-binding domain Putative DNA-binding domain superfamily SAND-like domain superfamily Ski-like, DNA-binding domain superfamily Ski oncogene SKI/SNO/DAC domain Transcription regulator SKI/SnoN
UniProtKB:Q9YI03 727
UniProtKB:B0S7D7 727
UniProtKB:Q1ECW8 727
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations