Gene

nog3

ID
ZDB-GENE-990714-8
Name
noggin 3
Symbol
nog3 Nomenclature History
Previous Names
  • zNog3
  • noggin
Type
protein_coding_gene
Location
Chr: 12 Mapping Details/Browsers
Description
Involved in several processes, including embryonic viscerocranium morphogenesis; negative regulation of BMP signaling pathway; and urogenital system development. Predicted to localize to extracellular space. Is expressed in cartilage element; fin; head; and otic vesicle. Human ortholog(s) of this gene implicated in Huntington's disease; cleft lip; dysostosis (multiple); hyperopia; and proximal symphalangism. Orthologous to human NOG (noggin).
Genome Resources
Note
None
Expression
All Expression Data
12 figures from 7 publications
Cross-Species Comparison
High Throughput Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
Fig. 6 from Ning et al., 2013
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With nog3 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
brachydactyly type B2 Alliance Brachydactyly, type B2 611377
multiple synostoses syndrome Alliance Multiple synostoses syndrome 1 186500
proximal symphalangism Alliance Symphalangism, proximal, 1A 185800
tarsal-carpal coalition syndrome Alliance Tarsal-carpal coalition syndrome 186570
Stapes ankylosis with broad thumbs and toes 184460
Associated With nog3 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Family IPR008717 Noggin
Homologous_superfamily IPR029034 Cystine-knot cytokine
Domain Details Per Protein
Protein Length Cystine-knot cytokine Noggin
UniProtKB:Q9YHV3 223
UniProtKB:E7FFB8 223
UniProtKB:Q6ZM29 223
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations