ZFIN ID: ZDB-GENE-990714-3
Gene Name: glycogen synthase kinase 3 alpha b
Gene Symbol: gsk3ab    Nomenclature History

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Previous Names: GSK-3[a] (1), gsk3a

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 16 Mapping Details/Browsers
Description: Predicted to have protein serine/threonine kinase activity. Involved in cardiac muscle cell development; dorsal/ventral pattern formation; and heart looping. Predicted to localize to axon; cytosol; and nucleus. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis. Orthologous to human GSK3A (glycogen synthase kinase 3 alpha).
Genome Resources: Alliance (1),  Gene:30664 (1),  Ensembl(GRCz11):ENSDARG00000015681 (2)
GENE EXPRESSION
High Throughput Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa22769 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa42670 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-gsk3ab N/A 2
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH gsk3ab HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH gsk3ab VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process dorsal/ventral pattern formation (more)
    Cellular Component axon (more)
    Molecular Function ATP binding (more)
    GO Terms (all 21)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    aberrant processed transcript gsk3ab-203 (1)    Ensembl 576
    mRNA gsk3ab-201 (1)    Ensembl 2971
    ncRNA gsk3ab-003 (1)    Ensembl 901
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM gsk3ab No data available
    MARKER RELATIONSHIPS
    gsk3ab Contained in: [BAC] DKEY-165G20 (1) (order this)
    gsk3ab Encodes: [cDNA] MGC:65742 (1), MGC:76825 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_131390 (1) 3100 nt
    Genomic GenBank:CR848744 (1) 246497 nt Blast at MegaBLAST
    Polypeptide UniProtKB:Q9YH61 (1) 440 aa
    Sequence Information (all 20)
    ORTHOLOGY for gsk3ab ( Chr: 16 )
    CITATIONS (30)