Gene

eya1

ID
ZDB-GENE-990712-18
Name
EYA transcriptional coactivator and phosphatase 1
Symbol
eya1 Nomenclature History
Previous Names
  • dog eared (1)
  • dog (1)
  • wu:fc13c10
  • zgc:100770
Type
protein_coding_gene
Location
Chr: 24 Mapping Details/Browsers
Description
Predicted to enable protein tyrosine phosphatase activity. Acts upstream of or within adenohypophysis development; otic vesicle morphogenesis; and otolith development. Predicted to be active in nucleus. Is expressed in several structures, including adenohypophyseal placode; brain; ectoderm; head; and lateral line system. Human ortholog(s) of this gene implicated in branchiootorenal syndrome and branchiootorenal syndrome 1. Orthologous to human EYA1 (EYA transcriptional coactivator and phosphatase 1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
70 figures from 46 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
17 figures from 7 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With eya1 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
branchiootic syndrome Alliance Anterior segment anomalies with or without cataract 602588
branchiootic syndrome Alliance Branchiootic syndrome 1 602588
branchiootorenal syndrome 1 Alliance Branchiootorenal syndrome 1, with or without cataracts 113650
?Otofaciocervical syndrome 166780
Associated With eya1 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR006545 EYA domain
Domain IPR042577 EYA domain, metazoan
Family IPR028471 Eyes absent homologue 1
Family IPR028472 Eyes absent family
Homologous_superfamily IPR038102 EYA domain superfamily
Domain Details Per Protein
Protein Length EYA domain EYA domain, metazoan EYA domain superfamily Eyes absent family Eyes absent homologue 1
UniProtKB:A8KBN8 587
UniProtKB:F1QNU4 609
UniProtKB:Q9W6E8 609
UniProtKB:E9QJ32 592
UniProtKB:A0A2R8QQM8 213
UniProtKB:E9QII4 86
UniProtKB:Q6DBY3 587
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations