Gene

wif1

ID
ZDB-GENE-990712-17
Name
wnt inhibitory factor 1
Symbol
wif1 Nomenclature History
Previous Names
  • zgc:110507 (1)
Type
protein_coding_gene
Location
Chr: 4 Mapping Details/Browsers
Description
Predicted to have signaling receptor binding activity. Involved in negative regulation of canonical Wnt signaling pathway and swim bladder development. Predicted to localize to cell surface and extracellular region. Is expressed in several structures, including anterior swim bladder bud; nervous system; paraxial mesoderm; pharyngeal arch; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in breast cancer; renal cell carcinoma; and urinary bladder cancer. Orthologous to human WIF1 (WNT inhibitory factor 1).
Genome Resources
Note
None
Expression
All Expression Data
18 figures from 11 publications
Cross-Species Comparison
High Throughput Data
No data available
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
4 figures from Yin et al., 2012
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With wif1 Human Ortholog
No data available
Associated With wif1 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR013032 EGF-like, conserved site
Domain IPR000742 EGF-like domain
Domain IPR003306 WIF domain
Domain IPR013111 EGF-like domain, extracellular
Family IPR013309 Wnt inhibitory factor (WIF)-1
Homologous_superfamily IPR038677 WIF domain superfamily
Domain Details Per Protein
Protein Length EGF-like, conserved site EGF-like domain EGF-like domain, extracellular WIF domain WIF domain superfamily Wnt inhibitory factor (WIF)-1
UniProtKB:Q9W6F9 378
UniProtKB:Q5TZI0 378
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Gene Tree
Ensembl
Citations