ZFIN Gene: wif1

ZFIN ID: ZDB-GENE-990712-17

ZFIN ID: ZDB-GENE-990712-17

Gene Name:

wnt inhibitory factor 1

Gene Symbol:

wif1

Sequence Ontology ID :

SO:0000704

Previous Name:

zgc:110507 (1)

Location:

Chr: 4 Mapping Details/Browsers

Nomenclature History

AUTOMATED DESCRIPTION

Predicted to have signaling receptor binding activity. Involved in negative regulation of canonical Wnt signaling pathway and swim bladder development. Predicted to localize to the cell surface and ...

GENE EXPRESSION
All Expression Data:	16 figures from 9 publications
Directly Submitted Expression Data:	6 figures (19 images) from Thisse et al., 2005 [eu316]
Wild-type Stages, Structures:	Blastula:Sphere (4.0h-4.33h) to Larval:Protruding-mouth (72.0h-96.0h, 3.5mm)
	anterior swim bladder bud diencephalon horizontal myoseptum hypothalamus lateral line lateral line system midbrain notochord pancreas paraxial mesoderm pectoral fin pharyngeal arch pharyngeal arch 3-7 pneumatic duct presumptive paraxial mesoderm segmental plate swim bladder epithelium swim bladder swim bladder bud ventral root whole organism
Curated Microarray Expression:	GEO (1)

MUTATIONS AND SEQUENCE TARGETING REAGENTS

Allele	Type	Localization	Consequence	Mutagen	Suppliers
la028970Tg	Transgenic Insertion	Unknown	Unknown	DNA

Targeting reagents:

PHENOTYPE

Data:	4 figures from Yin et al., 2012
Observed in:	anterior swim bladder bud canonical Wnt signaling pathway pancreas smooth muscle tissue development somite swim bladder epithelium swim bladder mesenchyme swim bladder swim bladder development trunk tunica interna swim bladder smooth muscle visceral peritoneum

DISEASE ASSOCIATED WITH wif1 HUMAN ORTHOLOG No data available

DISEASE ASSOCIATED WITH wif1 VIA EXPERIMENTAL MODELS No data available

GENE ONTOLOGY

Ontology	GO Term
Biological Process	negative regulation of canonical Wnt signaling pathway (more)
Cellular Component	extracellular region (more)
Molecular Function	signaling receptor binding (more)

GO Terms (all 9)

PROTEIN FAMILIES, DOMAINS AND SITES
InterPro:IPR000742 (1) InterPro:IPR003306 (1) InterPro:IPR013032 (1) InterPro:IPR013111 (1) InterPro:IPR013309 (1) InterPro:IPR038677 (1)	PROSITE:PS00022 (1) PROSITE:PS01186 (1) PROSITE:PS50026 (1) PROSITE:PS50814 (1)	Pfam:PF02019 (1) Pfam:PF07974 (1) Pfam:PF12661 (1)

TRANSCRIPTS
Type	Name	Length (bp)	Analysis
mRNA	wif1-201 (1)	1883	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

GENE PRODUCT DESCRIPTION

INTERACTIONS AND PATHWAYS

ANTIBODIESNo data available

PLASMIDSNo data available

CONSTRUCTS WITH SEQUENCES FROM wif1 No data available

MARKER RELATIONSHIPS

wif1Contained in:	[BAC] DKEY-6A5 (1) (order this)
wif1Encodes:	[EST] eu316 (1) [cDNA] MGC:110507 (1) (order this), MGC:192912 (1) (order this)

SEQUENCE INFORMATION

Type	Accession #	Length (bp/aa)	Analysis
RNA	RefSeq:NM_131229 (1)	1897bp	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
Genomic	GenBank:BX119963 (1)	229125bp	Blast at MegaBLAST
Polypeptide	UniProtKB:Q5TZI0 (1)	378aa	Select Tool ZFIN BLAST SIB BLAST Ensembl Protein Blast
Sequence Clusters	UniGene:3690 (1)

Sequence Information (all 22)

OTHER wif1 GENE PAGES

Alliance (1)

Gene:30476 (1)

VEGA:OTTDARG00000007871 (1)

Ensembl(GRCz11):ENSDARG00000005541 (2)

ORTHOLOGY for wif1 (Chr: 4)

CITATIONS (43)

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